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arXiv · 0709.1012

Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

Anna Salvati·Sandra Ristori·Daniela Pietrangeli·Julian Oberdisse·Luca Calamai·Giacomo Martini·Giampaolo Ricciardi
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Abstract

The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis- (1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20- porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and ζpotential measurements in order to define the overall properties and structural details of loaded liposomes.

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Anna Salvati, Sandra Ristori, Daniela Pietrangeli, Julian Oberdisse, Luca Calamai, Giacomo Martini, Giampaolo Ricciardi. 2007-09-07. Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study. https://arxiv.org/abs/0709.1012

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