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arXiv · 0709.3602

Time and length scales of autocrine signals in three dimensions

Mathieu Coppey·Alexander M. Berezhkovskii·Stuart C. Sealfon·Stanislav Y. Shvartsman
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Abstract

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

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Mathieu Coppey, Alexander M. Berezhkovskii, Stuart C. Sealfon, Stanislav Y. Shvartsman. 2007-09-22. Time and length scales of autocrine signals in three dimensions. https://doi.org/10.1529/biophysj.107.109736

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