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arXiv · 0808.2424

The age incidence of any cancer can be explained by a one-mutation model

Rinaldo B. Schinazi
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Abstract

We propose a one mutation model for cancer with a mutation rate that increases with time. Under rather general hypotheses the number of mutations is necessarily a (non homogeneous) Poisson process with the prescribed mutation rate. We show that the cumulative probability of cancer up to time $t$ is, up to a multiplicative constant, an antiderivative of the mutation rate.

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Rinaldo B. Schinazi. 2008-08-18. The age incidence of any cancer can be explained by a one-mutation model. https://arxiv.org/abs/0808.2424

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