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arXiv · 0906.2504

Isotropic-nematic phase transition in amyloid fibrilization

Chiu Fan Lee
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Abstract

We carry out a theoretical study on the isotropic-nematic phase transition and phase separation in amyloid fibril solutions. Borrowing the thermodynamic model employed in the study of cylindrical micelles, we investigate the variations in the fibril length distribution and phase behavior with respect to changes in the protein concentration, fibril's rigidity, and binding energy. We then relate our theoretical findings to the nematic ordering observed in Hen Lysozyme fibril solution.

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Chiu Fan Lee. 2009-08-11. Isotropic-nematic phase transition in amyloid fibrilization. https://doi.org/10.1103/physreve.80.031902

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