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arXiv · 1010.4629

The Role of Family-Based Designs in Genome-Wide Association Studies

Nan M. Laird·Christoph Lange
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Abstract

Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.

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Nan M. Laird, Christoph Lange. 2010-10-22. The Role of Family-Based Designs in Genome-Wide Association Studies. https://doi.org/10.1214/08-sts280

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