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arXiv · 1101.4240

Information transmission in genetic regulatory networks: a review

Aleksandra M Walczak·Gašper Tkačik
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Abstract

Genetic regulatory networks enable cells to respond to the changes in internal and external conditions by dynamically coordinating their gene expression profiles. Our ability to make quantitative measurements in these biochemical circuits has deepened our understanding of what kinds of computations genetic regulatory networks can perform and with what reliability. These advances have motivated researchers to look for connections between the architecture and function of genetic regulatory networks. Transmitting information between network's inputs and its outputs has been proposed as one such possible measure of function, relevant in certain biological contexts. Here we summarize recent developments in the application of information theory to gene regulatory networks. We first review basic concepts in information theory necessary to understand recent work. We then discuss the functional complexity of gene regulation which arrises from the molecular nature of the regulatory interactions. We end by reviewing some experiments supporting the view that genetic networks responsible for early development of multicellular organisms might be maximizing transmitted 'positional' information.

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Aleksandra M Walczak, Gašper Tkačik. 2011-01-21. Information transmission in genetic regulatory networks: a review. https://doi.org/10.1088/0953-8984%2F23%2F15%2F153102

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