The dynamics of H-bonds of the hydration shells of ions, ATPase and NE-activated adenylyl cyclase on the coupling of energy and signal transduction

Alfred Bennun

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arXiv · 1208.5673

The dynamics of H-bonds of the hydration shells of ions, ATPase and NE-activated adenylyl cyclase on the coupling of energy and signal transduction

Alfred Bennun

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Abstract

Glycerol titration distinguished from free water the local hydration shell involved in ATPase transition from active to inactive, with cooperativity for water n=16. Rat brain cortex: NE-stimulated and its basal AC in the absence of free Mg2+, allows a refractive state of AC with negative cooperativity for MgATP and ATP4-. The erythrocyte-Hb system operates as a metabolic sensor to match glucose availability with the release of Hb-carried, O2 and Mg2+ at CSF. [Mg(H2O)6](H2O)122+ by chelating either a protein or ATP4- losses most of its hydration shell. The ion pump ATPase by forming ADP3- releases an incompletely hydrated Mg2+, which could capture H2O from either [Na.(H2O)6]+ or [K.(H2O)6]+. Thus, sieve-sizing their hydration shells for fitting into Na+-pump channels. An AC refractory period may participate in STM. Mg2+ with cooperativity n=3.7 activates NE-AC. CREB-generated receptors coupled by Mg2+ may modulate hydration shells-dependent oscillations for retrieval of LTM

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Alfred Bennun. 2012-07-17. The dynamics of H-bonds of the hydration shells of ions, ATPase and NE-activated adenylyl cyclase on the coupling of energy and signal transduction. https://arxiv.org/abs/1208.5673

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