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arXiv · 1302.2041

Pattern Analysis of Tandem Repeats in Nlrp1

Sim-Hui Tee
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Abstract

Pattern analysis of tandem repeats in gene is an indispensable computational approach to the understanding of the gene expression and pathogenesis of diseases. This research applied a computational motif model and database techniques to study the distribution of tandem repeats in Nlrp1 gene, which is a critical gene to detect the invading pathogens in the immunologic mechanisms. The frequency of tandem repeats in Nlrp1 gene was studied for mono-, di-, tri-, and tetranucleotides. Mutations of Nlrp1 gene were analyzed to identify the insertion,deletion, and substitution of nucleotides. The results of this research provide a basis for future work in computational drug design and biomedical engineering in tackling diseases associated with immune system.

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Sim-Hui Tee. 2013-02-08. Pattern Analysis of Tandem Repeats in Nlrp1. https://arxiv.org/abs/1302.2041

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