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arXiv · 1308.5906

Biological effects and equivalent doses in radiotherapy: a software solution

Cyril Voyant·Daniel Julian·Rudy Roustit·Katia Biffi·Celine Lantieri Marcovici
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Abstract

The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers.

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Cyril Voyant, Daniel Julian, Rudy Roustit, Katia Biffi, Celine Lantieri Marcovici. 2013-08-23. Biological effects and equivalent doses in radiotherapy: a software solution. https://arxiv.org/abs/1308.5906

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