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arXiv · 1310.0606

Deciding whether follow-up studies have replicated findings in a preliminary large-scale "omics' study"

Ruth Heller·Marina Bogomolov·Yoav Benjamini
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Abstract

We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e. needles in a haystack). Our proposal assigns an $r$-value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available.

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Ruth Heller, Marina Bogomolov, Yoav Benjamini. 2014-06-10. Deciding whether follow-up studies have replicated findings in a preliminary large-scale "omics' study". https://doi.org/10.1073/pnas.1314814111

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