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arXiv · 1401.6445

Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors

Hamid Teimouri·Anatoly B. Kolomeisky·Kareem Mehrabiani
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Abstract

Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials. We investigate the fundamental role of these interactions by analyzing a new class of totally asymmetric exclusion processes where interactions are accounted for in a thermodynamically consistent fashion. Theoretical analysis that combines various mean-field cal- culations and computer simulations suggests that dynamic properties of molecular motors strongly depend on interactions, and correlations are stronger for interacting motor proteins. Surprisingly, it is found that there is an optimal strength of interactions (weak repulsion) that leads to a maxi- mal particle flux. It is also argued that molecular motors transport is more sensitive to attractive interactions. Applications of these results for kinesin motor proteins are discussed.

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Hamid Teimouri, Anatoly B. Kolomeisky, Kareem Mehrabiani. 2014-01-24. Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors. https://doi.org/10.1088/1751-8113/48/6/065001

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