Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 1403.8032

Large number of endemic equilibria for disease transmission models in patchy environment

Diána H. Knipl·Gergely Röst
View original source ↗Read source document ↗Export metadata ↓

Abstract

We show that disease transmission models in a spatially heterogeneous environment can have a large number of coexisting endemic equilibria. A general compartmental model is considered to describe the spread of an infectious disease in a population distributed over several patches. For disconnected regions, many boundary equilibria may exist with mixed disease free and endemic components, but these steady states usually disappear in the presence of spatial dispersal. However, if backward bifurcations can occur in the regions, some partially endemic equilibria of the disconnected system move into the interior of the nonnegative cone and persist with the introduction of mobility between the patches. We provide a mathematical procedure that precisely describes in terms of the local reproduction numbers and the connectivity network of the patches, whether a steady state of the disconnected system is preserved or ceases to exist for low volumes of travel. Our results are illustrated on a patchy HIV transmission model with subthreshold endemic equilibria and backward bifurcation. We demonstrate the rich dynamical behavior (i.e., creation and destruction of steady states) and the presence of multiple stable endemic equilibria for various connection networks.

Explore related subjects

math.CAq-bio.PE

Keep this discovery

BibTeXRIS

Diána H. Knipl, Gergely Röst. 2014-03-31. Large number of endemic equilibria for disease transmission models in patchy environment. https://arxiv.org/abs/1403.8032

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

On the log-concavity of the composite Bessel function $x^{\alpha}J_{\nu }\left( \beta x^{\gamma}\right) $

For a twice differentiable function $f:\left( a,b\right) \rightarrow \mathbb{R}$ define $v\left( f\right) =f^{\prime}f^{\prime}-f^{\prime\prime }f.$ It is well known that the positivity of $v\left( f\right) $ implies that the function $\left\vert f\right\vert $ is strictly log-concave on each subinterval which does not contain zeros of $f.$ In this paper we provide criteria for the positivity of $v\left( F\right) $ for the composite Bessel function $F\left( x\right) =J_{\alpha,\beta,\gamma,\nu}\left( x\right) :=x^{\alpha}J_{\nu}\left( \beta x^{\gamma}\right) $ for positive numbers $\beta$ and $\gamma$ and real numbers $\alpha$ and $\nu.$

math.CA↗
arXiv2026

Riesz capacity ratios with negative exponents

We investigate sharp inequalities for ratios of Riesz capacities with negative exponents by combining computational experiments with rigorous analysis. For finite subsets of the line, we prove positivity of equilibrium masses when $-1<p<0$, enabling numerical tests of conjectured extremal ratios. In the plane, comparisons of the disk with regular polygon vertex sets reveal a cascade of transitions among the tested competitors and suggest a precise conjecture for the equilibrium measure of odd polygons, for which we give a partial proof. Numerical intersections of equality curves show that the regions where these sets outperform the disk are not simply nested. Similar numerical intersections occur in three dimensions between the regular-simplex equality curve and those of explicit five-point and six-point configurations. Motivated by the dimensional dependence of these comparisons, we prove that for each fixed $p<-2<q<0$, the regular simplex has a larger capacity ratio than the ball in all sufficiently large dimensions. Accompanying Python and Mathematica code supports reproduction and further testing of the conjectures.

math.CA↗
arXiv2026

Shorter proof of dimension-free $L^p$ estimates for maximal Riesz transforms

We provide a shorter and more direct proof of $L^p$ estimates for maximal Riesz transforms (of an arbitrary order) in terms of the corresponding Riesz transforms, with a constant independent of the dimension of the Euclidean space $\mathbb R^d$. This result was originally proved by Mateu, Orobitg, P\'erez and Verdera with a constant depending on the dimension, and improved to a dimension-free inequality by Kucharski, Wr\'obel and Zienkiewicz.

math.CA↗