Host-to-host variation of ecological interactions in polymicrobial infections

Abstract

Host-to-host variability with respect to interactions between microorganisms and multicellular hosts are commonly observed in infection and in homeostasis. However, the majority of mechanistic models used in analyzing host-microorganism relationships, as well as most of the ecological theories proposed to explain co-evolution of host and microbes, are based on averages across a host population. By assuming that observed variations are random and independent, these models overlook the role of inter-host differences. Here we analyze mechanisms underlying host-to-host variations, using the well-characterized experimental infection model of polymicrobial otitis media (OM) in chinchillas, in combination with population dynamic models and a Maximum Entropy (MaxEnt) based inference scheme. We find that the nature of the interactions among bacterial species critically regulates host-to-host variations of these interactions. Surprisingly, seemingly unrelated phenomena, such as the efficiency of individual bacterial species in utilizing nutrients for growth and the microbe-specific host immune response, can become interdependent in a host population. The latter finding suggests a potential mechanism that could lead to selection of specific strains of bacterial species during the coevolution of the host immune response and the bacterial species.