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arXiv · 1405.2635

Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy

Xiao-Dong Zhang·Zhentao Luo·Jie Chen·Xiu Shen·Shasha Song·Yuanming Sun·Saijun Fan·Feiyue Fan·David Tai Leong·Jianping Xie
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Abstract

Radiosensitizers can increase the local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, we report a new class of radiosensitizers that contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12(SG)10-12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.

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Xiao-Dong Zhang, Zhentao Luo, Jie Chen, Xiu Shen, Shasha Song, Yuanming Sun, Saijun Fan, Feiyue Fan, David Tai Leong, Jianping Xie. 2014-05-12. Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy. https://doi.org/10.1002/adma.201400866

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