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arXiv · 1501.06725

Mathematical modeling of lymphocytes selection in the germinal center

Vuk Milisic·Gilles Wainrib
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Abstract

Lymphocyte selection is a fundamental operation of adaptive immunity. In order to produce B-lymphocytes with a desired antigenic profile, a process of mutation-selection occurs in the germinal center, which is part of the lymph nodes. We introduce in this article a simplified mathematical model of this process, taking into account the main mechanisms of division, mutation and selection. This model is written as a non-linear, non-local, inhomogeneous second order partial differential equation, for which we develop a mathematical analysis in the case of piecewise-constant coefficients. We assess, mathematically and numerically, the performance of the biological function by evaluating the duration of this production process as a function of several parameters such as the mutation rate or the selection profile, in various asymptotic regimes.

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Vuk Milisic, Gilles Wainrib. 2015-01-27. Mathematical modeling of lymphocytes selection in the germinal center. https://arxiv.org/abs/1501.06725

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