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arXiv · 1602.07264

A Multivariate Biomarker for Parkinson's Disease

Giancarlo Crocetti·Michael Coakley·Phil Dressner·Wanda Kellum·Tamba Lamin
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Abstract

In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a complete data analysis and during the exploratory phase, we selected a list of differentially expressed genes. Despite their association with the diseased state, we could not use them as a biomarker tool. Therefore, our research was extended to include a multivariate analysis approach resulting in the identification and selection of a group of 20 genes that showed a clear potential in detecting and correctly classify Parkinson Disease samples even in the presence of other neurodegenerative disorders.

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Giancarlo Crocetti, Michael Coakley, Phil Dressner, Wanda Kellum, Tamba Lamin. 2015-05-15. A Multivariate Biomarker for Parkinson's Disease. https://arxiv.org/abs/1602.07264

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