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arXiv · 1608.08064

Spheroidal and Nanocrystal Structures From Carbodiimide Crosslinking Reaction With RADA16

Jorge Monreal·Robert Hyde
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Abstract

RADA16 is a widely studied polypeptide known for its ability to self-assemble into $\beta$-sheets that form nanofibers. Here we show that it is possible to self-crosslink the molecule via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as aqueous solutions. The product results in a mix of nanocrystals and near micron-size spherules. SEM and TEM pictures provide a view of the structures and nano tracking analysis give their size distributions. FTIR analysis provides evidence for the existence of a crosslinking reaction.

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Jorge Monreal, Robert Hyde. 2016-08-29. Spheroidal and Nanocrystal Structures From Carbodiimide Crosslinking Reaction With RADA16. https://arxiv.org/abs/1608.08064

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