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arXiv · 1610.01127

Mechanism for long-acting chimeras based on fusion with the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin beta-subunit 3

J. C. Phillips
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Abstract

Thermodynamic scaling explains the dramatic successes of CTP fused human growth proteins as regards lifetime in vivo and enhanced functionality compared to their wild-type analogues, like Biogen. The theory is semi-quantitative and contains no adjustable parameters. It shows how hydrophilic terminal spheres orient fused proteins in the neighborhood of a membrane surface, extending lifetimes and improving functionality.

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J. C. Phillips. 2016-10-04. Mechanism for long-acting chimeras based on fusion with the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin beta-subunit 3. https://arxiv.org/abs/1610.01127

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