Investigations of dynamic light scattering properties in fluorescent solution: A comprehensive study using plasmonic enhanced Flow-Cytometry

Martin Michelswirth; Julia Hengster; Tobias Milde; Thomas Gaumnitz; Natalie Wagner; Patrick Theato; Klaus Liefeith; Thorsten Uphues

arXiv · 1701.07296

Investigations of dynamic light scattering properties in fluorescent solution: A comprehensive study using plasmonic enhanced Flow-Cytometry

Martin Michelswirth·Julia Hengster·Tobias Milde·Thomas Gaumnitz·Natalie Wagner·Patrick Theato·Klaus Liefeith·Thorsten Uphues

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Abstract

In this article we present a new diagnostic approach utilizing flow-cytometry to study compounds of nanoparticle samples in solution by analysis of their scattering patterns retrieved from the cytometric measurements. As a specific enhancement of this technique we study as well the scattering pattern of nanoparticles in a fluorescent solution (529 nm). A significant enhancement of the cytometry measurements is observed supporting an improved separation of particle formations that are clearly resolved in the cytograms. The samples in this experiment are prepared from 80 nm citrate-capped gold nanoparticles (AuNP). They are stabilized providing 2-(dimethylamino)ethanol (DMAE) in the aqueous solution. A laser diode with a wavelength of 488 nm is used as fundamental illumination for the flow-cytometry measurements (FCM). Dynamic Light Scattering (DLS) measurements are performed separately and demonstrate a very good agreement with the Flow-Cytometry measurements both of which allow to give an effective size calibration. For further analysis light transport simulations are presented. They provide information on the key-process to form the correlation of the fluorescent solutions FCM to the studied particles of interest. From this we extract the volume nature of the scattering process ensuring the correlation.

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Martin Michelswirth, Julia Hengster, Tobias Milde, Thomas Gaumnitz, Natalie Wagner, Patrick Theato, Klaus Liefeith, Thorsten Uphues. 2017-01-25. Investigations of dynamic light scattering properties in fluorescent solution: A comprehensive study using plasmonic enhanced Flow-Cytometry. https://arxiv.org/abs/1701.07296

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