Estimation of Tissue Microstructure Using a Deep Network Inspired by a Sparse Reconstruction Framework

Chuyang Ye

Home/Archive/arXiv

arXiv · 1704.01246

Estimation of Tissue Microstructure Using a Deep Network Inspired by a Sparse Reconstruction Framework

Chuyang Ye

View original source ↗Read source document ↗Export metadata ↓

Abstract

Diffusion magnetic resonance imaging (dMRI) provides a unique tool for noninvasively probing the microstructure of the neuronal tissue. The NODDI model has been a popular approach to the estimation of tissue microstructure in many neuroscience studies. It represents the diffusion signals with three types of diffusion in tissue: intra-cellular, extra-cellular, and cerebrospinal fluid compartments. However, the original NODDI method uses a computationally expensive procedure to fit the model and could require a large number of diffusion gradients for accurate microstructure estimation, which may be impractical for clinical use. Therefore, efforts have been devoted to efficient and accurate NODDI microstructure estimation with a reduced number of diffusion gradients. In this work, we propose a deep network based approach to the NODDI microstructure estimation, which is named Microstructure Estimation using a Deep Network (MEDN). Motivated by the AMICO algorithm which accelerates the computation of NODDI parameters, we formulate the microstructure estimation problem in a dictionary-based framework. The proposed network comprises two cascaded stages. The first stage resembles the solution to a dictionary-based sparse reconstruction problem and the second stage computes the final microstructure using the output of the first stage. The weights in the two stages are jointly learned from training data, which is obtained from training dMRI scans with diffusion gradients that densely sample the q-space. The proposed method was applied to brain dMRI scans, where two shells each with 30 gradient directions (60 diffusion gradients in total) were used. Estimation accuracy with respect to the gold standard was measured and the results demonstrate that MEDN outperforms the competing algorithms.

Explore related subjects

cs.CV

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

Chuyang Ye. 2017-04-05. Estimation of Tissue Microstructure Using a Deep Network Inspired by a Sparse Reconstruction Framework. https://arxiv.org/abs/1704.01246

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

SSP-GNN: Learning to Track via Bilevel Optimization

We propose a graph-based tracking formulation for multi-object tracking (MOT) where target detections contain kinematic information and re-identification features (attributes). Our method applies a successive shortest paths (SSP) algorithm to a tracking graph defined over a batch of frames. The edge costs in this tracking graph are computed via a message-passing network, a graph neural network (GNN) variant. The parameters of the GNN, and hence, the tracker, are learned end-to-end on a training set of example ground-truth tracks and detections. Specifically, learning takes the form of bilevel optimization guided by our novel loss function. We evaluate our algorithm on simulated scenarios to understand its sensitivity to scenario aspects and model hyperparameters. Across varied scenario complexities, our method compares favorably to a strong baseline.

cs.CV↗

arXiv2026

AdaptiveCDM: Source-Free Few-Shot Domain Adaptation for Cell Detection in Microscopic Images

Cross-domain cell detection for microscopic images suffers from performance degradation due to distribution shifts across imaging domains. Unsupervised Domain Adaptation (UDA) strategies, attempt to overcome domain sift without requiring annotated data from target. However, requirement of availability of annotated data from the source domain and large-size data from target domain are both challenging limitations for realistic scenarios. This is especially true in medical imaging, where privacy requirements might prevent access to annotated source data, and costly data acquisition restricts extensive sampling of the target domain. To address these challenges, we propose AdaptiveCDM, a modular framework for Source-Free Few-Shot Domain Adaptive Object Detection (SF-FSDAOD) setting, that adapts a pretrained source model using only few labeled target images without accessing source data. AdaptiveCDM combines Resolution-Aware Augmentation (RAug) and Category-Aware Representation Learning (CARL). RAug alleviates the scarcity and class imbalance by augmenting instance balanced training examples, while preserving the scale fidelity and morphological properties of cellular structures. CARL enhances discriminative representation learning by encouraging class-consistent proposals, improving both localization and classification. We also introduce two competitive baselines for proposed setting: Faster-FreeShot and MT-FreeShot. Our approach achieves 40.4/43.4 mAP0.5 on M5 and 67.1/75.5 mAP0.5 on Raabin-WBC under 2-/5-shot adaptation. Despite using only a few labeled target images and no source data, AdaptiveCDM achieves competitive or superior performance compared with SOTA methods under their respective supervision settings. Ablations and qualitative analyses further substantiate the contribution of each component and the effectiveness of AdaptiveCDM in low-data regimes. Code/models will be available.

cs.CV↗

arXiv2026

Uncertainty-Weighted Fusion of Image and Synthetic Event for Video Anomaly Detection

Most existing video anomaly detectors rely on RGB frames alone, which limit their ability to capture abrupt or transient motion cues that are critical for identifying anomalous events. We propose Uncertainty Weighted Image Event Fusion (IEF-VAD), a framework that integrates complementary RGB and synthetic motion information through a principled weighting mechanism. The method models the high variance and heavy tailed characteristics of synthetic motion cues with a Student's t likelihood, computes value level inverse variance weights using a Laplace approximation to prevent the image modality from overshadowing motion information, and performs iterative refinement to suppress residual cross modal noise. This formulation provides a more balanced and reliable fusion process compared to cross attention or gating based approaches that often suffer from modality dominance. Without requiring an event camera or frame level annotations, IEF-VAD achieves new state of the art performance on multiple real world anomaly detection benchmarks and remains stable under degradation applied to individual modalities. The results indicate that extracting and integrating complementary motion cues is an effective direction for robust video understanding across diverse environments.

cs.CV↗