Prevalent Intrinsic Emission from Nonaromatic Amino Acids and Poly(Amino Acids)

Abstract

Nonaromatic amino acids are generally believed to be nonemissive, owing to their lack of apparently remarkable conjugation within individual molecules. Here we report the intrinsic visible emission of nonaromatic amino acids and poly(amino acids) in concentrated solutions and solid powders. This unique and widespread luminescent characteristic can be well rationalized by the clustering-triggered emission (CTE) mechanism, namely the clustering of nonconventional chromophores (i.e. amino, carbonyl, and hydroxyl) and subsequent electron cloud overlap with simultaneously conformation rigidification. Such CTE mechanism is further supported by the single crystal structure analysis. Besides prompt fluorescence, room temperature phosphorescence (RTP) are also detected from the solids. Moreover, persistent RTP is observed in the powders of exampled poly(amino acid) of {\epsilon}-poly-L-lysine ({\epsilon}-PLL) after ceasing UV irradiation. These results not only illustrate the feasibility of employing the building blocks of nonaromatic amino acids in the exploration of new luminescent biomolecules, but also provide significant implications for the RTP of peptides and proteins at aggregated or crystalline states.