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arXiv · 1708.06451

Optimal control of a delayed HIV model

Filipe Rodrigues·Cristiana J. Silva·Delfim F. M. Torres·Helmut Maurer
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Abstract

We propose a model for the human immunodeficiency virus type 1 (HIV-1) infection with intracellular delay and prove the local asymptotical stability of the equilibrium points. Then we introduce a control function representing the efficiency of reverse transcriptase inhibitors and consider the pharmacological delay associated to the control. Finally, we propose and analyze an optimal control problem with state and control delays. Through numerical simulations, extremal solutions are proposed for minimization of the virus concentration and treatment costs.

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Filipe Rodrigues, Cristiana J. Silva, Delfim F. M. Torres, Helmut Maurer. 2017-08-21. Optimal control of a delayed HIV model. https://doi.org/10.3934/dcdsb.2018030

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