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arXiv · 1710.03127

Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables

Michael Grayling·James Wason·Adrian Mander
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Abstract

In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative and economic benefits. In this work, we discuss a collection of new Stata commands for computing the stopping boundaries and required group size of various classical group sequential designs, assuming a normally distributed outcome variable. Following this, we demonstrate how the performance of several designs can be compared graphically.

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Michael Grayling, James Wason, Adrian Mander. 2017-11-28. Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables. https://arxiv.org/abs/1710.03127

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