Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells

Oleksii Zdorevskyi; Dmytro Piatnytskyi; Sergey N. Volkov

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arXiv · 1811.11026

Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells

Oleksii Zdorevskyi·Dmytro Piatnytskyi·Sergey N. Volkov

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Abstract

After irradiation of cancer cells in the ion beam therapy method the concentration of hydrogen peroxide in the cell medium grows significantly. But the role of hydrogen peroxide molecules in cancer treatment has not been determined yet. We assume that interaction of peroxide molecules with DNA atomic groups can block the genetic information of the cancer cell and lead to its neutralization. To understand the possibility of DNA deactivation in the cell, in the present study the formation of complexes of hydrogen peroxide molecules with DNA specific recognition sites (nucleic bases) is considered. Using atom-atom potential functions method and quantum-chemical approach, based on density functional theory, the spatial configurations and energy minima for the complexes of peroxide and water molecules with nucleic bases are studied. The most probable positions of hydrogen peroxide molecules interacting with nucleic bases are determined, and the possibility of blocking of genetic information transfer processes is shown. The obtained data allows us to formulate a new mechanism of the ion irradiation action on living cells, that can be useful for cancer treatment.

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Oleksii Zdorevskyi, Dmytro Piatnytskyi, Sergey N. Volkov. 2018-11-27. Blocking of DNA specific recognition sites by hydrogen peroxide molecules in the process of ion beam therapy of cancer cells. https://arxiv.org/abs/1811.11026

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