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arXiv · 2006.00822

What do we know about DNA mechanics so far?

Abhishek Aggarwal·Supriyo Naskar·Anil Kumar Sahoo·Santosh Mogurampelly·Ashok Garai·Prabal K. Maiti
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Abstract

The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and find applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.

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physics.bio-phcond-mat.softcond-mat.stat-mechphysics.chem-ph

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Abhishek Aggarwal, Supriyo Naskar, Anil Kumar Sahoo, Santosh Mogurampelly, Ashok Garai, Prabal K. Maiti. 2020-06-01. What do we know about DNA mechanics so far?. https://doi.org/10.1016/j.sbi.2020.05.010

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