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arXiv · 2009.12110

Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology

Ludwig A. Hothorn·Dimitrios Spiliotopoulos
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Abstract

To claim similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology is a relevant issue during the assay validation process. Here we demonstrated the use of dose-by-laboratory interaction contrasts, particularly Williams-type by total mean contrasts. With the CRAN packages statint and multcomp in the open-source software R the estimation of adjusted p-values or compatible simultaneous confidence intervals is relatively easy. The interpretation in terms of global or partial equivalence, i.e. similarity, is challenging, because thresholds are not available a-priori. This approach is demonstrated by selected in-vitro Ames MPF assay data.

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Ludwig A. Hothorn, Dimitrios Spiliotopoulos. 2020-09-25. Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology. https://arxiv.org/abs/2009.12110

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