Size-adjustable Ring-shape Photoacoustic Tomography System

Abstract

Photoacoustic tomography (PAT) combines the advantages of the spectroscopic optical absorption contrast and acoustic resolution with deep penetration, and becomes an important novel biomedical imaging technology for scientific research and clinical diagnosis. In this paper, an imaging size-adjustable PAT system is proposed for clinical applications, which can adapt for different size imaging targets. Comparing with the conventional PAT system setup which with a fixed radius ring shape ultrasound transducer (UT) array, the proposed system, which is based on sectorial ultrasound transducer array (SUTA), is more flexible for different size targets imaging. There are 32 elements for each SUTA, and four SUTAs form a 128-channel UT array for photoacoustic wave detection. The four SUTAs are controlled by four stepper motors, and change the SUTAs distribute positon that adapt for imaging applications. The radius of the proposed system imaging region of interest (ROI) can be adjusted from 50 mm to 90 mm, which is much more flexible than the conventional full ring UT array PAT system. The simulation results generated by the MATLAB k-wave toolbox very well demonstrate the feasibility of the proposed system. To further validate the proposed system for size-adjustable imaging, a vascular mimicking phantom and ex-vivo pork breast with indocyanine green (ICG) injected are imaged to prove its feasibility for clinical applications.