Highly coordinated nationwide massive travel restrictions are central to effective mitigation and control of COVID-19 outbreaks in China

Abstract

The COVID-19, the disease caused by the novel coronavirus 2019 (SARS-CoV-2), has caused graving woes across the globe since first reported in the epicenter Wuhan, Hubei, China, December 2019. The spread of COVID-19 in China has been successfully curtailed by massive travel restrictions that put more than 900 million people housebound for more than two months since the lockdown of Wuhan on 23 January 2020 when other provinces in China followed suit. Here, we assess the impact of China's massive lockdowns and travel restrictions reflected by the changes in mobility patterns before and during the lockdown period. We quantify the synchrony of mobility patterns across provinces and within provinces. Using these mobility data, we calibrate movement flow between provinces in combination with an epidemiological compartment model to quantify the effectiveness of lockdowns and reductions in disease transmission. Our analysis demonstrates that the onset and phase of local community transmission in other provinces depends on the cumulative population outflow received from the epicenter Hubei. As such, infections can propagate further into other interconnected places both near and far, thereby necessitating synchronous lockdowns. Moreover, our data-driven modeling analysis shows that lockdowns and consequently reduced mobility lag a certain time to elicit an actual impact on slowing down the spreading and ultimately putting the epidemic under check. In spite of the vastly heterogeneous demographics and epidemiological characteristics across China, mobility data shows that massive travel restrictions have been applied consistently via a top-down approach along with high levels of compliance from the bottom up.