Search arXivSearch

arXiv · 2206.04451

Deep kernelization for the Tree Bisection and Reconnnect (TBR) distance in phylogenetics

Abstract

We describe a kernel of size 9k-8 for the NP-hard problem of computing the Tree Bisection and Reconnect (TBR) distance k between two unrooted binary phylogenetic trees. We achieve this by extending the existing portfolio of reduction rules with three novel new reduction rules. Two of the rules are based on the idea of topologically transforming the trees in a distance-preserving way in order to guarantee execution of earlier reduction rules. The third rule extends the local neighbourhood approach introduced in (Kelk and Linz, Annals of Combinatorics 24(3), 2020) to more global structures, allowing new situations to be identified when deletion of a leaf definitely reduces the TBR distance by one. The bound on the kernel size is tight up to an additive term. Our results also apply to the equivalent problem of computing a Maximum Agreement Forest (MAF) between two unrooted binary phylogenetic trees. We anticipate that our results will be more widely applicable for computing agreement-forest based dissimilarity measures.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Steven Kelk, Simone Linz, Ruben Meuwese. 2022-09-20. Deep kernelization for the Tree Bisection and Reconnnect (TBR) distance in phylogenetics. https://arxiv.org/abs/2206.04451

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

The Marked Edge Walk: A Novel MCMC Algorithm for Sampling of Graph Partitions

Novel Markov Chain Monte Carlo (MCMC) methods have enabled the generation of large ensembles of redistricting plans modeled as a graph partitioning problem. However, existing algorithms such as Reversible Recombination (RevReCom) and Metropolized Forest Recombination (MFR) have strong preferences for distributions related to the spanning tree measure. In this paper we introduce the Marked Edge Walk (MEW), a novel Markov chain proposal for sampling from the space of graph partitions. The walk operates on the space of spanning trees with marked edges, allowing for calculable transition probabilities for use in the Metropolis-Hastings algorithm. Empirical results on real-world dual graphs show convergence under a broad class of target distributions less constrained by spanning tree counts, including policy-based distributions, such as competitiveness on New Hampshire that are independent of spanning trees, and compactness and partisan symmetry distributions on New Hampshire and Texas that, while related to spanning trees, can now be properly targeted with a smaller degree of spanning tree bias, which represents an advancement in flexible ensemble generation.

cs.DS

The Price of Privacy For Approximating Max-CSP

We study approximation algorithms for Maximum Constraint Satisfaction Problems (Max-CSPs) under differential privacy (DP) where the constraints are considered sensitive data. Information-theoretically, we aim to classify the best approximation ratios possible for a given privacy budget $\varepsilon$. In the high-privacy regime ($\varepsilon \ll 1$), we show that any $\varepsilon$-DP algorithm cannot beat a random assignment by more than $O(\varepsilon)$ in the approximation ratio. We devise a polynomial-time algorithm which matches this barrier under the assumptions that the instances are bounded-degree and triangle-free. Finally, we show that one or both of these assumptions can be removed for specific CSPs--such as Max-Cut or Max $k$-XOR--albeit at the cost of computational efficiency.

cs.DS

Distributed Santa Claus via Global Rounding

In this paper, we initiate the study of a new class of problems in the CONGEST model: Mixed packing and covering linear programs (LP). Previously, the design of optimization algorithms in the distributed setting was heavily focused on solving linear programs with either packing or covering constraints. We are the first to explore the class of linear programs with both packing and covering constraints by providing a general-purpose CONGEST solver for such LPs and by studying the sequentially well-studied Santa Claus problem as a central representative. This NP-hard problem can be modeled as a bipartite graph of children and gifts where an edge indicates that a child desires a gift. The goal is to assign the gifts to the children such that the least happy child is as happy as possible. Even though this is a well-studied problem in the sequential setting, we provide the first results in the distributed setting. In particular, we show that the complexity of computing an $\mathcal{O}(\log n/\log \log n)$-approximation is $\widehat Θ(\sqrt n+D)$ rounds, where our $\widetildeΩ(\sqrt n+D)$-round lower bound even holds for any approximation.

cs.DS