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arXiv · 2206.15164

Magnetometry of neurons using a superconducting qubit

Hiraku Toida·Koji Sakai·Tetsuhiko F. Teshima·Masahiro Hori·Kosuke Kakuyanagi·Imran Mahboob·Yukinori Ono·Shiro Saito
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Abstract

We demonstrate magnetometry of cultured neurons on a polymeric film using a superconducting flux qubit that works as a sensitive magnetometer in a microscale area. The neurons are cultured in Fe$^{3+}$ rich medium to increase magnetization signal generated by the electron spins originating from the ions. The magnetometry is performed by insulating the qubit device from the laden neurons with the polymeric film while keeping the distance between them around several micrometers. By changing temperature (12.5 - 200 mK) and a magnetic field (2.5 - 12.5 mT), we observe a clear magnetization signal from the neurons that is well above the control magnetometry of the polymeric film itself. From electron spin resonance (ESR) spectrum measured at 10 K, the magnetization signal is identified to originate from electron spins of iron ions in neurons. This technique to detect a bio-spin system can be extended to achieve ESR spectroscopy at the single-cell level, which will give the spectroscopic fingerprint of cells.

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Hiraku Toida, Koji Sakai, Tetsuhiko F. Teshima, Masahiro Hori, Kosuke Kakuyanagi, Imran Mahboob, Yukinori Ono, Shiro Saito. 2022-06-30. Magnetometry of neurons using a superconducting qubit. https://doi.org/10.1038/s42005-023-01133-z

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