Unraveling heterogeneity of ADNI's time-to-event data using conditional entropy Part-I: Cross-sectional study

Shuting Liao; Fushing Hsieh

Home/Archive/arXiv

arXiv · 2211.15763

Unraveling heterogeneity of ADNI's time-to-event data using conditional entropy Part-I: Cross-sectional study

Shuting Liao·Fushing Hsieh

View original source ↗Read source document ↗Export metadata ↓

Abstract

Through Alzheimer's Disease Neuroimaging Initiative (ADNI), time-to-event data: from the pre-dementia state of mild cognitive impairment (MCI) to the diagnosis of Alzheimer's disease (AD), is collected and analyzed by explicitly unraveling prognostic heterogeneity among 346 uncensored and 557 right censored subjects under structural dependency among covariate features. The non-informative censoring mechanism is tested and confirmed based on conditional-vs-marginal entropies evaluated upon contingency tables built by the Redistribute-to-the-right algorithm. The Categorical Exploratory Data Analysis (CEDA) paradigm is applied to evaluate conditional entropy-based associative patterns between the categorized response variable against 16 categorized covariable variables all having 4 categories. Two order-1 global major factors: V9 (MEM-mean) and V8 (ADAS13.bl) are selected sharing the highest amounts of mutual information with the response variable. This heavily censored data set is analyzed by Cox's proportional hazard (PH) modeling. Comparisons of PH and CEDA results on a global scale are complicated under the structural dependency of covariate features. To alleviate such complications, V9 and V8 are taken as two potential perspectives of heterogeneity and the entire collections of subjects are divided into two sets of four sub-collections. CEDA major factor selection protocol is applied to all sub-collections to figure out which features provide extra information. Graphic displays are developed to explicitly unravel conditional entropy expansions upon perspectives of heterogeneity in ADNI data. On the local scale, PH analysis is carried out and results are compared with CEDA's. We conclude that, when facing structural dependency among covariates and heterogeneity in data, CEDA and its major factor selection provide significant merits for manifesting data's multiscale information content.

Explore related subjects

stat.AP

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

Shuting Liao, Fushing Hsieh. 2022-11-28. Unraveling heterogeneity of ADNI's time-to-event data using conditional entropy Part-I: Cross-sectional study. https://arxiv.org/abs/2211.15763

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Geospatial Foundation Models Capture Health-Relevant Dimensions of Place Beyond Conventional Social Risk Indices

Area-based social risk indices summarize residents' socioeconomic conditions but incompletely capture physical features of place that may affect health. We evaluated whether numerical representations of physical place produced by four geospatial foundation model families from 2022 satellite data explained residual variance in tract-level associations between the Area Deprivation Index, Social Deprivation Index, and Social Vulnerability Index with health outcomes. We used LightGBM to predict variables from the American Community Survey and 40 chronic disease and health-behavior outcomes from CDC PLACES across 82,646 census tracts in the contiguous United States, evaluating performance across 10 held-out states. Among survey variables, models were moderately predictive of some variables including housing type (R-squared up to 0.54) but weak for disability, unemployment, and income disparity. For health outcomes, models explained up to 54% of variance left unexplained by social risk indices, with the largest gains for annual checkups, arthritis, and high blood pressure. Mean total variance explained by geospatial foundation models across the 40 health-related outcomes increased from 0.31 in the smallest tract-size decile to 0.39 in the largest. Geospatial foundation models capture health-relevant features of place not represented by conventional social risk indices and may usefully augment them in epidemiological analyses.

stat.AP↗

arXiv2026

Transporting summary measures of relative effects from randomised trials to the treated patient population: an application to breast cancer endocrine therapy

Randomised trials often report relative treatment effects, such as risk ratios and hazard ratios, for trial populations. Clinical decision-making, however, often benefits from estimates of absolute treatment effects in the population eligible for treatment. Trial participants may not represent this target population well, and restrictions on access to individual participant trial data can further complicate absolute effect estimation. Routine care data are often representative of the target population but may be subject to uncontrolled confounding. We consider estimation of the average treatment effect on the treated (ATT), an absolute measure, by combining a representative sample of treated routine care patients with summary measures (i.e., estimated risk or hazard ratios) from either a randomised trial or a meta-analysis of trials. Under marginal or conditional transportability assumptions, the ATT is shown to be identifiable. The implications of collapsibility of the effect measure on transportability are discussed, and plug-in estimators of the ATT are presented. Simulation studies are used to assess finite sample performance of the estimators in a range of settings. The proposed methods are applied to estimate the ATT of endocrine therapy on 15-year breast cancer mortality using results from a meta-analysis of randomised trials and England's National Disease Registration Service.

stat.AP↗

arXiv2026

Overcoming Model Misspecification in Bayesian Inference of Molecular Signalling Networks

Bayesian inference of molecular signalling networks usually relies on tractability of the marginal likelihood, enabling the set of possible networks to be efficiently explored. As such, linear models with independent errors and conjugate priors are routinely used. However, the dynamics of molecular signalling are nonlinear, and relevant confounders are often unobserved; failure to account for these complexities will almost certainly lead to over-confident inferences in the standard Bayesian framework. To confront this reality, we develop a post-Bayesian approach to inference of molecular signalling networks, guided by the principle that uncertainty should not vanish when the statistical model is misspecified, even in the infinite-data limit. Technically, we extend the predictively-oriented (PrO) posterior of McLatchie et al. (2025) to the setting of latent variable models, empirically investigating the properties of PrO posteriors in the challenging network inference context.

stat.AP↗