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arXiv · 2305.18958

Navier-Stokes Modelling of Non-Newtonian Blood Flow in Cerebral Arterial Circulation and its Dynamic Impact on Electrical Conductivity in a Realistic Multi-Compartment Head Model

Maryam Samavaki·Arash Zarrin Nia·Santtu Söderholm·Sampsa Pursiainen
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Abstract

Background and Objective: This study aims to evaluate the dynamic effect of non-Newtonian cerebral arterial circulation on electrical conductivity distribution (ECD) in a realistic multi-compartment head model. It addresses the importance and challenges associated with electrophysiological modalities, such as transcranial electrical stimulation, electro-magnetoencephalography, and electrical impedance tomography. Factors such as electrical conductivity's impact on forward modeling accuracy, complex vessel networks, data acquisition limitations (especially in MRI), and blood flow phenomena are considered. Methods: The Navier-Stokes equations (NSEs) govern the non-Newtonian flow model used in this study. The solver comprises two stages: the first solves the pressure field using a dynamical pressure-Poisson equation derived from NSEs, and the second updates the velocity field using Leray regularization and the pressure distribution from the first stage. The Carreau-Yasuda model establishes the connection between blood velocity and viscosity. Blood concentration in microvessels is approximated using Fick's law of diffusion, and conductivity mapping is obtained via Archie's law. The head model used corresponds to an open 7 Tesla MRI dataset, differentiating arterial vessels from other structures. Results: The results suggest the establishment of a dynamic model of cerebral blood flow for arterial and microcirculation. Blood pressure and conductivity distributions are obtained through numerically simulated pulse sequences, enabling approximation of blood concentration and conductivity within the brain. Conclusions: This model provides an approximation of dynamic blood flow and corresponding ECD in different brain regions. The advantage lies in its applicability with limited a priori information about blood flow and compatibility with arbitrary head models that distinguish arteries.

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Maryam Samavaki, Arash Zarrin Nia, Santtu Söderholm, Sampsa Pursiainen. 2023-05-30. Navier-Stokes Modelling of Non-Newtonian Blood Flow in Cerebral Arterial Circulation and its Dynamic Impact on Electrical Conductivity in a Realistic Multi-Compartment Head Model. https://arxiv.org/abs/2305.18958

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