3DTINC: Time-Equivariant Non-Contrastive Learning for Predicting Disease Progression from Longitudinal OCTs

Taha Emre; Arunava Chakravarty; Antoine Rivail; Dmitrii Lachinov; Oliver Leingang; Sophie Riedl; Julia Mai; Hendrik P. N. Scholl; Sobha Sivaprasad; Daniel Rueckert; Andrew Lotery; Ursula Schmidt-Erfurth; Hrvoje Bogunović

doi:10.1109/tmi.2024.3391215

arXiv · 2312.16980

3DTINC: Time-Equivariant Non-Contrastive Learning for Predicting Disease Progression from Longitudinal OCTs

Taha Emre·Arunava Chakravarty·Antoine Rivail·Dmitrii Lachinov·Oliver Leingang·Sophie Riedl·Julia Mai·Hendrik P. N. Scholl·Sobha Sivaprasad·Daniel Rueckert·Andrew Lotery·Ursula Schmidt-Erfurth·Hrvoje Bogunović

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Abstract

Self-supervised learning (SSL) has emerged as a powerful technique for improving the efficiency and effectiveness of deep learning models. Contrastive methods are a prominent family of SSL that extract similar representations of two augmented views of an image while pushing away others in the representation space as negatives. However, the state-of-the-art contrastive methods require large batch sizes and augmentations designed for natural images that are impractical for 3D medical images. To address these limitations, we propose a new longitudinal SSL method, 3DTINC, based on non-contrastive learning. It is designed to learn perturbation-invariant features for 3D optical coherence tomography (OCT) volumes, using augmentations specifically designed for OCT. We introduce a new non-contrastive similarity loss term that learns temporal information implicitly from intra-patient scans acquired at different times. Our experiments show that this temporal information is crucial for predicting progression of retinal diseases, such as age-related macular degeneration (AMD). After pretraining with 3DTINC, we evaluated the learned representations and the prognostic models on two large-scale longitudinal datasets of retinal OCTs where we predict the conversion to wet-AMD within a six months interval. Our results demonstrate that each component of our contributions is crucial for learning meaningful representations useful in predicting disease progression from longitudinal volumetric scans.

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Taha Emre, Arunava Chakravarty, Antoine Rivail, Dmitrii Lachinov, Oliver Leingang, Sophie Riedl, Julia Mai, Hendrik P. N. Scholl, Sobha Sivaprasad, Daniel Rueckert, Andrew Lotery, Ursula Schmidt-Erfurth, Hrvoje Bogunović. 2024-05-13. 3DTINC: Time-Equivariant Non-Contrastive Learning for Predicting Disease Progression from Longitudinal OCTs. https://doi.org/10.1109/tmi.2024.3391215

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