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arXiv · 2401.02149

AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Léna Carmès·Guillaume Bort·François Lux·Léa Seban·Paul Rocchi·Zeinaf Muradova·Agnès Hagège·Laurence Heinrich-Balard·Frédéric Delolme·Virginie Gueguen-Chaignon·Charles Truillet·Stephanie Crowley·Elisa Bello·Tristan Doussineau·Michael Dougan·Olivier Tillement·Jonathan Schoenfeld·Needa Brown·Ross Berbeco
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Abstract

Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints.

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Léna Carmès, Guillaume Bort, François Lux, Léa Seban, Paul Rocchi, Zeinaf Muradova, Agnès Hagège, Laurence Heinrich-Balard, Frédéric Delolme, Virginie Gueguen-Chaignon, Charles Truillet, Stephanie Crowley, Elisa Bello, Tristan Doussineau, Michael Dougan, Olivier Tillement, Jonathan Schoenfeld, Needa Brown, Ross Berbeco. 2024-01-04. AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors. https://doi.org/10.1039/d3nr04777f

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