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arXiv · 2402.02760

Proton-CAT: a Novel Strategy for Enhanced Proton Therapy

Zhao Sun·Zhencen He·Zhuohang He·Junxiang Wu·Liyuan Deng·Ziqi Chen·Junkang Jiang·Hang Zhu·Shuyu Zhang·Zhimin Hu
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Abstract

We present a nitrogen-targeting-Proton-Carbon-Alpha-Therapy method, abbreviated as Proton-CAT, which partially converts protons into carbon-12 and $α$ particles through nuclear reactions between protons and nitrogen-15. Monte Carlo simulations validated the effectiveness of the Proton-CAT, and the study specifically focused on the distribution of relative energy deposition. The results indicated that the presence of nitrogen-15 enhanced the maximum dose level of protons, resulting in more effective damage confined to tumor cells. Statistical analysis of secondary ions has shown that the Proton-CAT significantly increases the production efficiencies of carbon-12 and $α$ particles. Furthermore, it has been revealed that elevating the nitrogen-15 concentration significantly boosts the dose of carbon and $α$ particles within the tumor region. The present work would contribute to the future development of proton therapy.

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Zhao Sun, Zhencen He, Zhuohang He, Junxiang Wu, Liyuan Deng, Ziqi Chen, Junkang Jiang, Hang Zhu, Shuyu Zhang, Zhimin Hu. 2024-04-17. Proton-CAT: a Novel Strategy for Enhanced Proton Therapy. https://arxiv.org/abs/2402.02760

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