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arXiv · 2403.01219

Proton Resonance Shift Thermometry: A review of modern clinical practices

J. Blackwell·M. J. Krasny·A. O'Brien·K. Ashkan·J. Galligan·M. Destrade·N. Colgan
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Abstract

Magnetic Resonance Imaging (MRI) has become a popular modality in guiding minimally invasive thermal therapies, due to its advanced, non-ionizing, imaging capabilities and its ability to record changes in temperature. A variety of MR thermometry techniques have been developed over the years, and Proton Resonance Frequency (PRF) Shift Thermometry is the current clinical gold standard to treat a variety of cancers. It is used extensively to guide hyperthermic thermal ablation techniques such as high-intensity focused ultrasound (HIFU) and laser-induced thermal therapy (LITT). Essential attributes of PRF Shift Thermometry include excellent linearity with temperature, good sensitivity, and independence from tissue type. This non-invasive temperature mapping method gives accurate quantitative measures of the temperature evolution inside biological tissues. In this review, the current status and new developments in the fields of MR-guided HIFU and LITT are presented with an emphasis on breast, prostate, bone, uterine and brain treatments.

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J. Blackwell, M. J. Krasny, A. O'Brien, K. Ashkan, J. Galligan, M. Destrade, N. Colgan. 2024-03-02. Proton Resonance Shift Thermometry: A review of modern clinical practices. https://doi.org/10.1002/jmri.27446

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