White Matter Geometry-Guided Score-Based Diffusion Model for Tissue Microstructure Imputation in Tractography Imaging

Yui Lo; Yuqian Chen; Fan Zhang; Dongnan Liu; Leo Zekelman; Suheyla Cetin-Karayumak; Yogesh Rathi; Weidong Cai; Lauren J. O'Donnell

arXiv · 2407.19460

White Matter Geometry-Guided Score-Based Diffusion Model for Tissue Microstructure Imputation in Tractography Imaging

Yui Lo·Yuqian Chen·Fan Zhang·Dongnan Liu·Leo Zekelman·Suheyla Cetin-Karayumak·Yogesh Rathi·Weidong Cai·Lauren J. O'Donnell

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Abstract

Parcellation of white matter tractography provides anatomical features for disease prediction, anatomical tract segmentation, surgical brain mapping, and non-imaging phenotype classifications. However, parcellation does not always reach 100\% accuracy due to various factors, including inter-individual anatomical variability and the quality of neuroimaging scan data. The failure to identify parcels causes a problem of missing microstructure data values, which is especially challenging for downstream tasks that analyze large brain datasets. In this work, we propose a novel deep-learning model to impute tissue microstructure: the White Matter Geometry-guided Diffusion (WMG-Diff) model. Specifically, we first propose a deep score-based guided diffusion model to impute tissue microstructure for diffusion magnetic resonance imaging (dMRI) tractography fiber clusters. Second, we propose a white matter atlas geometric relationship-guided denoising function to guide the reverse denoising process at the subject-specific level. Third, we train and evaluate our model on a large dataset with 9342 subjects. Comprehensive experiments for tissue microstructure imputation and a downstream non-imaging phenotype prediction task demonstrate that our proposed WMG-Diff outperforms the compared state-of-the-art methods in both error and accuracy metrics. Our code will be available at: https://github.com/SlicerDMRI/WMG-Diff.

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Yui Lo, Yuqian Chen, Fan Zhang, Dongnan Liu, Leo Zekelman, Suheyla Cetin-Karayumak, Yogesh Rathi, Weidong Cai, Lauren J. O'Donnell. 2024-09-20. White Matter Geometry-Guided Score-Based Diffusion Model for Tissue Microstructure Imputation in Tractography Imaging. https://arxiv.org/abs/2407.19460

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