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arXiv · 2410.02050

A fast, flexible simulation framework for Bayesian adaptive designs -- the R package BATSS

Dominique-Laurent Couturier·Rainer Puhr·Stephane Heritier·Thomas Jaki·Elizabeth G Ryan
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Abstract

The use of Bayesian adaptive designs for randomised controlled trials has been hindered by the lack of software readily available to statisticians. We have developed a new software package (Bayesian Adaptive Trials Simulator Software - BATSS for the statistical software R, which provides a flexible structure for the fast simulation of Bayesian adaptive designs for clinical trials. We illustrate how the BATSS package can be used to define and evaluate the operating characteristics of Bayesian adaptive designs for various different types of primary outcomes (e.g., those that follow a normal, binary, Poisson or negative binomial distribution) and can incorporate the most common types of adaptations: stopping treatments (or the entire trial) for efficacy or futility, and Bayesian response adaptive randomisation - based on user-defined adaptation rules. Other important features of this highly modular package include: the use of (Integrated Nested) Laplace approximations to compute posterior distributions, parallel processing on a computer or a cluster, customisability, adjustment for covariates and a wide range of available conditional distributions for the response.

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Dominique-Laurent Couturier, Rainer Puhr, Stephane Heritier, Thomas Jaki, Elizabeth G Ryan. 2026-07-01. A fast, flexible simulation framework for Bayesian adaptive designs -- the R package BATSS. https://arxiv.org/abs/2410.02050

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