Indication Finding: a novel use case for representation learning

Maren Eckhoff; Valmir Selimi; Alexander Aranovitch; Ian Lyons; Emily Briggs; Jennifer Hou; Alex Devereson; Matej Macak; David Champagne; Chris Anagnostopoulos

arXiv · 2410.19174

Indication Finding: a novel use case for representation learning

Maren Eckhoff·Valmir Selimi·Alexander Aranovitch·Ian Lyons·Emily Briggs·Jennifer Hou·Alex Devereson·Matej Macak·David Champagne·Chris Anagnostopoulos

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Abstract

Many therapies are effective in treating multiple diseases. We present an approach that leverages methods developed in natural language processing and real-world data to prioritize potential, new indications for a mechanism of action (MoA). We specifically use representation learning to generate embeddings of indications and prioritize them based on their proximity to the indications with the strongest available evidence for the MoA. We demonstrate the successful deployment of our approach for anti-IL-17A using embeddings generated with SPPMI and present an evaluation framework to determine the quality of indication finding results and the derived embeddings.

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Maren Eckhoff, Valmir Selimi, Alexander Aranovitch, Ian Lyons, Emily Briggs, Jennifer Hou, Alex Devereson, Matej Macak, David Champagne, Chris Anagnostopoulos. 2024-10-24. Indication Finding: a novel use case for representation learning. https://arxiv.org/abs/2410.19174

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