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arXiv · 2412.17816

7 Tesla multimodal MRI dataset of ex-vivo human brain

Qinfeng Zhu·Sihui Li·Zuozhen Cao·Yao Shen·Haoan Xu·Guojun Xu·Haotian Li·Keqing Zhu·Zhiyong Zhao·Jing Zhang·Dan Wu
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Abstract

Ex-vivo MRI offers invaluable insights into the complexity of the human brain, enabling high-resolution anatomical delineation and integration with histopathology, and thus, contributes to both basic and clinical studies on normal and pathological brains. However, ex-vivo MRI is challenging in sample preparation, acquisition, and data analysis, and existing ex-vivo MRI datasets are often single image modality and lack of ethnic diversity. In our study, we aimed to address these limitations by constructing a comprehensive multimodal MRI database acquired from six ex-vivo Chinese human brains. This database included structural MRI, high-angular resolution diffusion MRI, quantitative susceptibility mapping, and quantitative T1 and T2 maps, which enabled multifaceted depiction of brain microstructure and connectivity. Furthermore, we generated population-averaged multimodal templates and the segmentation labels to facilitate analysis of ex-vivo brain MRI. This public database offers a collection of high-resolution and multi-parametric ex-vivo human brain MRI and filled the gap of lacking Asian brain samples in existing databases.

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Qinfeng Zhu, Sihui Li, Zuozhen Cao, Yao Shen, Haoan Xu, Guojun Xu, Haotian Li, Keqing Zhu, Zhiyong Zhao, Jing Zhang, Dan Wu. 2024-12-06. 7 Tesla multimodal MRI dataset of ex-vivo human brain. https://arxiv.org/abs/2412.17816

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