Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2503.05119

AI-driven Prediction of Insulin Resistance in Normal Populations: Comparing Models and Criteria

Weihao Gao·Zhuo Deng·Zheng Gong·Ziyi Jiang·Lan Ma
View original source ↗Read source document ↗Export metadata ↓

Abstract

Insulin resistance (IR) is a key precursor to diabetes and a significant risk factor for cardiovascular disease. Traditional IR assessment methods require multiple blood tests. We developed a simple AI model using only fasting blood glucose to predict IR in non-diabetic populations. Data from the NHANES (1999-2020) and CHARLS (2015) studies were used for model training and validation. Input features included age, gender, height, weight, blood pressure, waist circumference, and fasting blood glucose. The CatBoost algorithm achieved AUC values of 0.8596 (HOMA-IR) and 0.7777 (TyG index) in NHANES, with an external AUC of 0.7442 for TyG. For METS-IR prediction, the model achieved AUC values of 0.9731 (internal) and 0.9591 (external), with RMSE values of 3.2643 (internal) and 3.057 (external). SHAP analysis highlighted waist circumference as a key predictor of IR. This AI model offers a minimally invasive and effective tool for IR prediction, supporting early diabetes and cardiovascular disease prevention.

Explore related subjects

cs.LG

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Weihao Gao, Zhuo Deng, Zheng Gong, Ziyi Jiang, Lan Ma. 2025-03-07. AI-driven Prediction of Insulin Resistance in Normal Populations: Comparing Models and Criteria. https://arxiv.org/abs/2503.05119

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Analysis of Regularized Learning in Banach Spaces for Linear-functional Data

This article delves into the study of the theory of regularized learning in Banach spaces for linear-functional data. It encompasses discussions on representer theorems, pseudo-approximation theorems, and convergence theorems. Regularized learning is designed to minimize regularized empirical risks over a Banach space. The empirical risks are calculated by utilizing training data and multi-loss functions. The input training data are composed of linear functionals in a predual space of the Banach space to capture discrete local information from multimodal data and multiscale models. Through the regularized learning, approximations of the exact solution to an unidentified or uncertain original problem are globally achieved. In the convergence theorems, the convergence of the approximate solutions to the exact solution is established through the utilization of the weak* topology of the Banach space. The theorems of regularized learning are utilized in the interpretation of classical machine learning, such as support vector machines and artificial neural networks.

cs.LG↗
arXiv2026

On Minimal Depth in Neural Networks

Understanding the relationship between the depth of a neural network and its representational capacity is a central problem in deep learning theory. In this work, we develop a geometric framework to analyze the expressivity of ReLU networks with the notion of depth complexity for convex polytopes. The depth of a polytope recursively quantifies the number of alternating convex hull and Minkowski sum operations required to construct it. This geometric perspective serves as a rigorous tool for deriving depth lower bounds and understanding the structural limits of deep neural architectures. We establish lower and upper bounds on the depth of polytopes, as well as tight bounds for classical families. These results yield two main consequences. First, we provide a purely geometric proof of the expressivity bound by Arora et al. (2018), confirming that $\lceil \log_2(n+1)\rceil$ hidden layers suffice to represent any continuous piecewise linear (CPWL) function. Second, we prove that, unlike general ReLU networks, convex polytopes do not admit a universal depth bound. Specifically, the depth of cyclic polytopes in dimensions $n \geq 4$ grows unboundedly with the number of vertices. This result implies that Input Convex Neural Networks (ICNNs) cannot represent all convex CPWL functions with a fixed depth, revealing a sharp separation in expressivity between ICNNs and standard ReLU networks.

cs.LG↗
arXiv2026

DeepSPoC: A Deep Learning Based Sequential Propagation of Chaos

Classical particle methods based on propagation of chaos (PoC) have been developed for solving mean-field stochastic differential equations and their associated nonlinear Fokker--Planck equations. However, direct PoC implementations are difficult to apply to high-dimensional problems because they require simulating and storing large numbers of interacting particles, often with high particle-particle interaction costs. Motivated by these limitations, we build on the recently proposed sequential propagation of chaos (SPoC) framework, which replaces the fully interacting particle system in PoC with a sequential interaction mechanism. Based on this structure, we present DeepSPoC, a neural particle method that embeds a neural density representation into the sequential particle dynamics. DeepSPoC simulates particles batch by batch, while the neural network represents the evolving empirical law and is substituted into the coefficients of the mean-field SDE, thereby replacing direct particle-particle interactions with particle-network interactions. In DeepSPoC, a recently developed normalizing flow model called KRnet is used to approximate the empirical measure of particles. Compared with direct particle implementations, DeepSPoC substantially reduces memory consumption and evaluates interaction terms more efficiently, thereby improving scalability for high-dimensional problems. We apply DeepSPoC to a wide range of mean-field equations and verify its effectiveness and computational advantages.

cs.LG↗