An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection

Xian-Xian Liu; Yuanyuan Wei; Mingkun Xu; Yongze Guo; Hongwei Zhang; Huicong Dong; Qun Song; Qi Zhao; Wei Luo; Feng Tien; Juntao Gao; Simon Fong

arXiv · 2504.01038

An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection

Xian-Xian Liu·Yuanyuan Wei·Mingkun Xu·Yongze Guo·Hongwei Zhang·Huicong Dong·Qun Song·Qi Zhao·Wei Luo·Feng Tien·Juntao Gao·Simon Fong

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Abstract

Early detection of gastric cancer, a leading cause of cancer-related mortality worldwide, remains hampered by the limitations of current diagnostic technologies, leading to high rates of misdiagnosis and missed diagnoses. To address these challenges, we propose an integrated system that synergizes advanced hardware and software technologies to balance speed-accuracy. Our study introduces the One Class Twin Cross Learning (OCT-X) algorithm. Leveraging a novel fast double-threshold grid search strategy (FDT-GS) and a patch-based deep fully convolutional network, OCT-X maximizes diagnostic accuracy through real-time data processing and seamless lesion surveillance. The hardware component includes an all-in-one point-of-care testing (POCT) device with high-resolution imaging sensors, real-time data processing, and wireless connectivity, facilitated by the NI CompactDAQ and LabVIEW software. Our integrated system achieved an unprecedented diagnostic accuracy of 99.70%, significantly outperforming existing models by up to 4.47%, and demonstrated a 10% improvement in multirate adaptability. These findings underscore the potential of OCT-X as well as the integrated system in clinical diagnostics, offering a path toward more accurate, efficient, and less invasive early gastric cancer detection. Future research will explore broader applications, further advancing oncological diagnostics. Code is available at https://github.com/liu37972/Multirate-Location-on-OCT-X-Learning.git.

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Xian-Xian Liu, Yuanyuan Wei, Mingkun Xu, Yongze Guo, Hongwei Zhang, Huicong Dong, Qun Song, Qi Zhao, Wei Luo, Feng Tien, Juntao Gao, Simon Fong. 2025-03-31. An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection. https://arxiv.org/abs/2504.01038

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