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arXiv · 2507.07271

Beyond the ATE: Interpretable Modelling of Treatment Effects over Dose and Time

Julianna Piskorz·Krzysztof Kacprzyk·Harry Amad·Mihaela van der Schaar
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Abstract

The Average Treatment Effect (ATE) is a foundational metric in causal inference, widely used to assess intervention efficacy in randomized controlled trials (RCTs). However, in many applications -- particularly in healthcare -- this static summary fails to capture the nuanced dynamics of treatment effects that vary with both dose and time. We propose a framework for modelling treatment effect trajectories as smooth surfaces over dose and time, enabling the extraction of clinically actionable insights such as onset time, peak effect, and duration of benefit. To ensure interpretability, robustness, and verifiability -- key requirements in high-stakes domains -- we adapt SemanticODE, a recent framework for interpretable trajectory modelling, to the causal setting where treatment effects are never directly observed. Our approach decouples the estimation of trajectory shape from the specification of clinically relevant properties (e.g., maxima, inflection points), supporting domain-informed priors, post-hoc editing, and transparent analysis. We show that our method yields accurate, interpretable, and editable models of treatment dynamics, facilitating both rigorous causal analysis and practical decision-making.

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Julianna Piskorz, Krzysztof Kacprzyk, Harry Amad, Mihaela van der Schaar. 2025-07-21. Beyond the ATE: Interpretable Modelling of Treatment Effects over Dose and Time. https://arxiv.org/abs/2507.07271

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