Symmetry-breaking bifurcation of periodic solutions for a free-boundary tumor model

Wenhua He; Mingxin Wang; Ruixiang Xing

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arXiv · 2508.19954

Symmetry-breaking bifurcation of periodic solutions for a free-boundary tumor model

Wenhua He·Mingxin Wang·Ruixiang Xing

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Abstract

In this paper, we consider a free boundary multi-layer tumor model that incorporates a $T-$periodic provision of external nutrients $Φ(t)$. The simplified model contains three parameters: the mean of periodic external nutrients $Φ(t)$, the threshold concentration $\widetildeσ$ for proliferation and the cell to cell adhesiveness coefficient $γ$. We first study the flat solution and give a complete classification about $\frac{1}{T} \int_0^T Φ(t) d t$ and $\widetildeσ$ according to global stability of zero equilibrium solution or global stability of the positive periodic solution. Precisely, (i) a zero flat solution is globally stable under the flat perturbations if and only if $\widetildeσ \geqslant \frac{1}{T} \int_0^T Φ(t) d t$; (ii) If $\widetildeσ<\frac{1}{T} \int_0^T Φ(t) d t$, then there exists a unique positive flat solution $\left(σ_*(y, t), p_*(y, t), { ρ_*(t)}\right)$ with period $T$ and it is a global attractor of all positive flat solutions for all $γ>0$. We further investigate periodic solutions bifurcating from the flat periodic solution $\left(σ_*(y, t), p_*(y, t), { ρ_*(t)}\right)$. By periodicity and symmetry, we not only give symmetry-breaking periodic solutions for all positive parameter $γ_j$, but also show the existence of a plethora of periodic bifurcations. For the free boundary tumor problem, this is the first result of the existence of periodic bifurcations.

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BibTeX RIS

Wenhua He, Mingxin Wang, Ruixiang Xing. 2025-08-27. Symmetry-breaking bifurcation of periodic solutions for a free-boundary tumor model. https://arxiv.org/abs/2508.19954

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