Response function as a quantitative measure of consciousness in brain dynamics

Abstract

Understanding the neural correlates of consciousness remains a central challenge in neuroscience. In this study, we investigate the relationship between consciousness and neural responsiveness by analyzing intracranial ECoG recordings from non-human primates across three distinct states: wakefulness, anesthesia, and recovery. Using a nonequilibrium recurrent neural network (RNN) model, we fit state-dependent cortical dynamics to extract the neural response function as a dynamics complexity indicator. Our findings demonstrate that the amplitude of the neural response function serves as a robust dynamical indicator of conscious state, consistent with the role of a linear response function in statistical physics. Notably, this aligns with our previous theoretical results showing that the response function in RNNs peaks near the transition between ordered and chaotic regimes -- highlighting criticality as a potential principle for sustaining flexible and responsive cortical dynamics. Empirically, we find that during wakefulness, neural responsiveness is strong, widely distributed, and consistent with rich nonequilibrium fluctuations. Under anesthesia, response amplitudes are significantly suppressed, and the network dynamics become more chaotic, indicating a loss of dynamical sensitivity. During recovery, the neural response function is elevated, supporting the gradual re-establishment of flexible and responsive activity that parallels the restoration of conscious processing. Our work suggests that a robust, brain-state-dependent neural response function may be a necessary dynamical condition for consciousness, providing a principled framework for quantifying levels of consciousness in terms of nonequilibrium responsiveness in the brain.