Shape spectra of elastic shells with surface-adsorbed semiflexible polymers

Abstract

The shape of biological shells, such as cell nuclei, membranes, and vesicles, often deviates from a perfect sphere due to an interplay of complex interactions with a myriad of molecular structures. In particular, semiflexible biopolymers adsorbed to the surfaces of such shells seem to affect their morphological properties. While the effect of a single, long, semiflexible chain is relatively well characterized, the mechanisms by which a high density of such surface-adsorbed polymers can alter the morphology of a spherical, soft confinement, akin to biological shells, remain relatively poorly understood. Here, we use coarse-grained molecular dynamics simulations to investigate how surface adsorption of many semiflexible polymers affects the morphology of a pressurized bead-spring shell, which is spherical in the absence of these chains. By varying the attraction strength between the chains and the shell surface, chain concentration, and the polymerization degree of chains, we demonstrate that strong surface localization of the chains can induce severe shape distortions and shrinkage, depending on the chain length and concentration. Conversely, weak localization does not induce significant shape fluctuations, yet nematically ordered phases appear on the surface. Notably, these ordered phases lead to elliptic shell shapes for chains with sizes comparable to or longer than the radius of the confinement when the elastic shell is composed of extensible, harmonic bonds. Overall, our findings offer a strategy to control the shape of synthetic shells by manipulating peripheral localization and length of semiflexible polymers while suggesting a mechanism for non-spherical shapes appearing in some biological systems.