From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathology

Yizhi Wang; Li Chen; Qiang Huang; Tian Guan; Xi Deng; Zhiyuan Shen; Jiawen Li; Xinrui Chen; Bin Hu; Xitong Ling; Taojie Zhu; Zirui Huang; Deshui Yu; Yan Liu; Jiurun Chen; Lianghui Zhu; Qiming He; Yiqing Liu; Diwei Shi; Hanzhong Liu; Junbo Hu; Hongyi Gao; Zhen Song; Xilong Zhao; Chao He; Ming Zhao; Yonghong He

arXiv · 2510.10196

From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathology

View original source ↗Read source document ↗Export metadata ↓

Abstract

Cervical cancer remains a major malignancy, necessitating extensive and complex histopathological assessments and comprehensive support tools. Although deep learning shows promise, these models still lack accuracy and generalizability. General foundation models offer a broader reach but remain limited in capturing subspecialty-specific features and task adaptability. We introduce the Cervical Subspecialty Pathology (CerS-Path) diagnostic system, developed through two synergistic pretraining stages: self-supervised learning on approximately 190 million tissue patches from 140,000 slides to build a cervical-specific feature extractor, and multimodal enhancement with 2.5 million image-text pairs, followed by integration with multiple downstream diagnostic functions. Supporting eight diagnostic functions, including rare cancer classification and multimodal Q&A, CerS-Path surpasses prior foundation models in scope and clinical applicability. Comprehensive evaluations demonstrate a significant advance in cervical pathology, with prospective testing on 3,173 cases across five centers maintaining 99.38% screening sensitivity and excellent generalizability, highlighting its potential for subspecialty diagnostic translation and cervical cancer screening.

Explore related subjects

cs.CV

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

Yizhi Wang, Li Chen, Qiang Huang, Tian Guan, Xi Deng, Zhiyuan Shen, Jiawen Li, Xinrui Chen, Bin Hu, Xitong Ling, Taojie Zhu, Zirui Huang, Deshui Yu, Yan Liu, Jiurun Chen, Lianghui Zhu, Qiming He, Yiqing Liu, Diwei Shi, Hanzhong Liu, Junbo Hu, Hongyi Gao, Zhen Song, Xilong Zhao, Chao He, Ming Zhao, Yonghong He. 2025-10-11. From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathology. https://arxiv.org/abs/2510.10196

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Privacy Leakage on DNNs: A Survey of Model Inversion Attacks and Defenses

Deep Neural Networks (DNNs) have revolutionized various domains with their exceptional performance across numerous applications. However, Model Inversion (MI) attacks, which disclose private information about the training dataset by abusing access to the trained models, have emerged as a formidable privacy threat. Given a trained network, these attacks enable adversaries to reconstruct high-fidelity data that closely aligns with the private training samples, posing significant privacy concerns. Despite the rapid advances in the field, we lack a comprehensive and systematic overview of existing MI attacks and defenses. To fill this gap, this paper thoroughly investigates this realm and presents a holistic survey. Firstly, our work briefly reviews early MI studies on traditional machine learning scenarios. We then elaborately analyze and compare numerous recent attacks and defenses on Deep Neural Networks (DNNs) across multiple modalities and learning tasks. By meticulously analyzing their distinctive features, we summarize and classify these methods into different categories and provide a novel taxonomy. Finally, this paper discusses promising research directions and presents potential solutions to open issues. To facilitate further study on MI attacks and defenses, we have implemented an open-source model inversion toolbox on GitHub (https://github.com/ffhibnese/Model-Inversion-Attack-ToolBox).

cs.CV↗

arXiv2026

ALINA: Advanced Line Identification and Notation Algorithm

Labels are the cornerstone of supervised machine learning algorithms. Most visual recognition methods are fully supervised, using bounding boxes or pixel-wise segmentations for object localization. Traditional labeling methods, such as crowd-sourcing, are prohibitive due to cost, data privacy, amount of time, and potential errors on large datasets. To address these issues, we propose a novel annotation framework, Advanced Line Identification and Notation Algorithm (ALINA), which can be used for labeling taxiway datasets that consist of different camera perspectives and variable weather attributes (sunny and cloudy). Additionally, the CIRCular threshoLd pixEl Discovery And Traversal (CIRCLEDAT) algorithm has been proposed, which is an integral step in determining the pixels corresponding to taxiway line markings. Once the pixels are identified, ALINA generates corresponding pixel coordinate annotations on the frame. Using this approach, 60,249 frames from the taxiway dataset, AssistTaxi have been labeled. To evaluate the performance, a context-based edge map (CBEM) set was generated manually based on edge features and connectivity. The detection rate after testing the annotated labels with the CBEM set was recorded as 98.45%, attesting its dependability and effectiveness.

cs.CV↗

arXiv2026

DisasterInsight: A Building-Centric Benchmark for Evaluating Vision--Language Models in Disaster Response

Vision--language models (VLMs) show promise for disaster-response remote sensing, but existing benchmarks mainly emphasize scene-level or damage-centric assessment. To study this building-centric gap, we introduce \method{}, a diagnostic benchmark built on xBD, a pre/post-disaster satellite dataset with building-level damage labels. \method{} enriches building instances with OpenStreetMap-derived functional labels and contains 134{,}108 task-specific instruction records across 15 task types, spanning instance-level assessment, scene-level counting, multi-instance reasoning, and structured report generation. The benchmark supports RGB pre/post-disaster imagery, single- and multi-view instance formulations, and scene-level RGB/SAR diagnostic inputs. Experiments with general-domain and remote-sensing VLMs show that models perform better on visible damage cues than on building-function understanding, multi-instance reasoning, counting, and grounded reporting. Instruction tuning improves performance on several tasks but does not close this building-centric gap.

cs.CV↗