From Pixels to Views: Learning Angular-Aware and Physics-Consistent Representations for Light Field Microscopy

Feng He; Guodong Tan; Qiankun Li; Jun Yu; Quan Wen

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arXiv · 2510.22577

From Pixels to Views: Learning Angular-Aware and Physics-Consistent Representations for Light Field Microscopy

Feng He·Guodong Tan·Qiankun Li·Jun Yu·Quan Wen

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Abstract

Light field microscopy (LFM) has become an emerging tool in neuroscience for large-scale neural imaging in vivo, notable for its single-exposure volumetric imaging, broad field of view, and high temporal resolution. However, learning-based 3D reconstruction in XLFM remains underdeveloped due to two core challenges: the absence of standardized datasets and the lack of methods that can efficiently model its angular-spatial structure while remaining physically grounded. We address these challenges by introducing three key contributions. First, we construct the XLFM-Zebrafish benchmark, a large-scale dataset and evaluation suite for XLFM reconstruction. Second, we propose Masked View Modeling for Light Fields (MVN-LF), a self-supervised task that learns angular priors by predicting occluded views, improving data efficiency. Third, we formulate the Optical Rendering Consistency Loss (ORC Loss), a differentiable rendering constraint that enforces alignment between predicted volumes and their PSF-based forward projections. On the XLFM-Zebrafish benchmark, our method improves PSNR by 7.7% over state-of-the-art baselines.

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BibTeX RIS

Feng He, Guodong Tan, Qiankun Li, Jun Yu, Quan Wen. 2025-10-26. From Pixels to Views: Learning Angular-Aware and Physics-Consistent Representations for Light Field Microscopy. https://arxiv.org/abs/2510.22577

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