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arXiv · 2512.00063

Exploring the changes in brain network SC-FC coupling patterns of partial sleep deprivation based on DTI-fMRI fusion analysis

Mengyuan Liu·Jing Hu·Zhenzhen Ru·Ruomeng Quan·Xu Zhang·Ning Qiang·Jin Li
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Abstract

Sleep disorder is a serious global public health issue, with cognitive-emotional dysfunction being a core symptom. The analysis of multimodal MRI data provides an effective method for detecting sleep deprivation-induced neural network abnormalities. The structure-function coupling (SC-FC) integrates functional connectivity with white matter structural information, which can enable comprehensive detection of brain network abnormalities and offer quantitative measures of sleep deprivation-induced neural damage. This study integrates diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) to systematically investigate brain network reorganization and their relationship with emotional functions in partial sleep deprivation (PSD). Our methodology employed DTI to construct structural connectivity (SC) networks and rs-fMRI to establish functional connectivity (FC) networks, then construct SC-FC coupling model . The experiment included 16 healthy controls (HC) and 20 PSD patients, with comprehensive whole-brain and nodal-level SC-FC analyses performed. The results show that (1) severe FC disruptions in PSD patients involving the limbic system, default mode network, sensorimotor network, and visual networks; (2) altered SC in default mode, sensorimotor, visual, language, and auditory networks; (3) significant SC-FC decoupling in these networks; and (4) strong correlations between these neural changes and clinical measures (KSQ and HADS scores). The SC-FC coupling approach achieved comprehensive detection of PSD-related network abnormalities. Compared to single-modal approaches, this integrated SC-FC analysis provides more comprehensive biomarkers for sleep-related emotional dysregulation. This innovative multimodal neuroimaging approach elucidates the neural mechanisms of SC-FC imbalance induced by PSD, establishing novel biomarkers for sleep-mediated emotional dysregulation.

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Mengyuan Liu, Jing Hu, Zhenzhen Ru, Ruomeng Quan, Xu Zhang, Ning Qiang, Jin Li. 2025-11-24. Exploring the changes in brain network SC-FC coupling patterns of partial sleep deprivation based on DTI-fMRI fusion analysis. https://arxiv.org/abs/2512.00063

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