Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2512.15398

Mapis: A Knowledge-Graph Grounded Multi-Agent Framework for Evidence-Based PCOS Diagnosis

Zanxiang He·Meng Li·Liyun Shi·Weiye Daia·Liming Nie
View original source ↗Read source document ↗Export metadata ↓

Abstract

Polycystic Ovary Syndrome (PCOS) constitutes a significant public health issue affecting 10% of reproductive-aged women, highlighting the critical importance of developing effective diagnostic tools. Previous machine learning and deep learning detection tools are constrained by their reliance on large-scale labeled data and an lack of interpretability. Although multi-agent systems have demonstrated robust capabilities, the potential of such systems for PCOS detection remains largely unexplored. Existing medical multi-agent frameworks are predominantly designed for general medical tasks, suffering from insufficient domain integration and a lack of specific domain knowledge. To address these challenges, we propose Mapis, the first knowledge-grounded multi-agent framework explicitly designed for guideline-based PCOS diagnosis. Specifically, it built upon the 2023 International Guideline into a structured collaborative workflow that simulates the clinical diagnostic process. It decouples complex diagnostic tasks across specialized agents: a gynecological endocrine agent and a radiology agent collaborative to verify inclusion criteria, while an exclusion agent strictly rules out other causes. Furthermore, we construct a comprehensive PCOS knowledge graph to ensure verifiable, evidence-based decision-making. Extensive experiments on public benchmarks and specialized clinical datasets, benchmarking against nine diverse baselines, demonstrate that Mapis significantly outperforms competitive methods. On the clinical dataset, it surpasses traditional machine learning models by 13.56%, single-agent by 6.55%, and previous medical multi-agent systems by 7.05% in Accuracy.

Explore related subjects

cs.MA

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Zanxiang He, Meng Li, Liyun Shi, Weiye Daia, Liming Nie. 2025-12-17. Mapis: A Knowledge-Graph Grounded Multi-Agent Framework for Evidence-Based PCOS Diagnosis. https://arxiv.org/abs/2512.15398

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

REAT: A Reflective Experience-Augmented Tutoring Framework for Multi-turn Mathematical Instruction

Current Large Language Models (LLMs) excel at solving complex mathematical problems, yet this proficiency does not inherently translate into effective tutoring. While advanced LLM tutors may leverage multi-agent frameworks or fine-tuning, most still lack a mechanism to systematically accumulate and reuse pedagogical experience over time, limiting their adaptability to diverse student needs during fluid, multi-turn interactions. To bridge this gap, we propose the Reflective Experience-Augmented Tutoring (REAT) framework, which couples experience distillation from historical dialogues with real-time adaptive retrieval. Driven by a multi-agent Observer-Critic-Mentor (OCM) distillation pipeline, REAT reviews past conversational trajectories and distills raw interactions into structured, problem-agnostic pedagogical experiences. During live tutoring, a state-aware retrieval module injects these curated experiences to provide adaptive scaffolding based on the student's cognitive state. Experiments demonstrate that the proposed framework significantly outperforms both prompt-only and supervised fine-tuning (SFT) baselines, particularly in improving complex, low-scoring tutoring scenarios. Crucially, the distilled experiences exhibit robust generalization across diverse model architectures and mathematical datasets.

cs.MA↗
arXiv2026

Optimization without Future Compromises? Decentralized Coordination via Collective and Reinforcement Learning

Efficient resource allocation in multi-agent systems requires autonomous agents to coordinate their decisions while balancing system-wide objectives with individual costs. This becomes increasingly challenging over long time horizons, where decisions that improve the current allocation may compromise future resource allocation, while decentralized agents have limited observations of the overall system. Multi-agent reinforcement learning (MARL) can learn such long-term dependencies via local observations, but directly applying it to large-scale coordination leads to rapidly growing decision spaces and inefficient training. To this end, we propose Hierarchical Reinforcement and Collective Learning (HRCL), a hierarchical framework that uses MARL to guide, rather than replace, decentralized multi-agent coordination. At the high level, MARL learns strategies that restrict the alternatives considered during coordination and guide agents in balancing system-wide and individual objectives. At the low level, agents perform efficient decentralized coordination under this strategic guidance. This separation reduces the learning space and allows short-term coordination trade-offs to be evaluated according to their long-term effects. Experiments on a synthetic benchmark show that HRCL converges substantially faster than standalone MARL and reduces system-wide and individual costs by 35.53% and 27.05%, respectively. Evaluations on energy self-management and drone swarm sensing further show improved resource allocation, power-peak regulation, and sensing efficiency. These results show that learning strategic guidance for an existing coordination process can retain scalable decentralized coordination without letting short-term decisions compromise future resource allocation.

cs.MA↗
arXiv2026

Multi-robot Graph Traversal with Support Coordination under Stochastically Moving Adversaries

Cooperative multi-robot missions require team of robots to traverse environments where adversaries or hazards with stochastic dynamics induce time-varying traversal risk. While support coordination--where robots assist teammates in traversing risky regions--can significantly reduce mission costs, its effectiveness depends on the team's ability to anticipate future risk. We formulate support-based multi-robot graph traversal problem with stochastically moving adversaries, where future risky regions become uncertain as adversaries move through the environment. When adversaries remain stationary, our formulation reduces to the static risky-edge setting. To address the stochastic case, we model individual adversaries as first-order Markov stay-move processes over graph edges and propagate their occupancy distributions over a finite planning horizon to obtain time-indexed edge-risk forecasts. These forecasts inform the support candidate selection and joint robot path planning. Experimental results show that forecast-informed support decisions consistently lower expected team cost relative to evaluated baselines in stochastic motion settings.

cs.MA↗